Jennifer Loschwitz
PhD Student
Curriculum Vitae
since 2018
PhD student at the Computational Biochemistry Group at ICS-6: Structural Biochemistry, Forschungszentrum Jülich, Germany. The PhD is funded by the SFB 1208.
2017
Research Assistant at the Gohlke Group at Institute of Pharmaceutical and Medical Chemistry, Heinrich-Heine University, Germany.
2014 – 2017
MSc in Biochemistry at the Heinrich-Heine University, Germany. The MSc thesis was supervised by Prof. Dr. Holger Gohlke.
2011 – 2014
BSc in Biochemistry at the Heinrich-Heine University, Germany. The BSc thesis was supervised by Jun.-Prof. Dr. Birgit Strodel.
Research interests
- Interactions of protein-membrane systems using MD and CG simulations
- Amyloid protein aggregation using MD simulations
PhD Project
I‘m working on protein-membrane interations of murine guanylate binding proteins (mGBPs) on the membrane via all-atomic and coarse-grained MD simulations. Furthermore, my interest lies in working on Aβ and SARS-CoV-2.
Publications
Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2
J. Loschwitz, N. Steffens, X. Wang, M. Schäffler, K. Pfeffer, D. Degrandi, B. Strodel
Scientific Reports 13 (1), 1-20 (2023) [link]
Development of a first-in-class small molecule inhibitor of the C-terminal Hsp90 dimerization
Bhatia, S., Spanier, L., Bickel, D., Dienstbier, N., Woloschin, V., Vogt, M., Pols, H., Lungerich, B., Reiners, J., Aghaallaei, N., Diedrich, D., Frieg, B, Schliehe-Diecks, J., Bopp, B., Lang, F., Gopalswamy, M., Loschwitz, J., Bajohgli, B., Skokowa, J., Borkhardt, A., Hauer, J., Hansen, F.K., Smits, S.H.J., Jose, J., Gohlke, H., Kurz, T.
ChemRxiv. Cambridge: Cambridge Open Engage (2021) [link]
Disorder-to-order transition of the amyloid-β peptide upon lipid binding
H. Fatafta, B. Kav, B.F. Bundschuh, J. Loschwitz, B. Strodel
Biophys. Chem., accepted (2021) [link]
Dataset of AMBER force field parameters of drugs, natural products and steroids for simulations using GROMACS
J. Loschwitz, A. Jäckering, M. Keutmann, M. Olagunju, O. O. Olubiyi, B Strodel
Data in Brief 35, 106948 (2021) [link]
Novel Inhibitors of the Main Protease of SARS-CoV-2 Identified via a Molecular Dynamics Simulation-Guided in Vitro Assay
J. Loschwitz, A. Jäckering, M. Keutmann, M. Olagunju, R. J. Eberle, M. A. Coronado, O. O. Olubiyi, B. Strodel
Bioorg. Chem. 111, 104862 (2021) [link]
High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
O. O. Olubiyi, M. Olagunju, M. Keutmann, J. Loschwitz, B. Strodel
Molecules 25, 3193 (2020) [link]
Computer simulations of protein-membrane systems
J. Loschwitz, O. O.Olubiyi, J. S.Hub, B. Strodel, C. S.Poojari
Prog. Mol. Biol. Transl. Sci. 170, 273-403 (2020) [link]
Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail
L. Legewie, J. Loschwitz, N. Steffens, M. Prescher, X. Wang, S.H.J. Smits, L. Schmitt, B. Strodel, D. Degrandi, K. Pfeffer
Biochem. J. 476, 3161-3182 (2019) [link]
Large-scale, dynamin-like motions of the human guanylate binding protein 1 revealed by multi-resolution simulations
B. Barz, J. Loschwitz, B. Strodel
PLOS Comp. Biol., 15, e1007193 (2019) [link]
Interference with Amyloid-β Nucleation by Transient Ligand Interactoin
T. Zhang, J. Loschwitz, B. Strodel, L. Nagel-Steger, D. Willbold
Molecules, 24, 2129 (2019) [link]
